100000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 100020 - Disclosure - Fair Value of Financial Assets and Liabilities - Financial Assets and Liabilities that were Subject to Fair Value Measurement on Recurring Basis (Detail) 2 link:presentationLink link:calculationLink link:definitionLink 100030 - Disclosure - Leases - Schedule of Future Annual Minimum Lease Payments (Detail) 2 link:presentationLink link:calculationLink link:definitionLink 100040 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100050 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 100060 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 100070 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 100080 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 100090 - Disclosure - Nature of the Business link:presentationLink link:calculationLink link:definitionLink 100100 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 100110 - Disclosure - Fair Value of Financial Assets and Liabilities link:presentationLink link:calculationLink link:definitionLink 100120 - Disclosure - Marketable Securities link:presentationLink link:calculationLink link:definitionLink 100130 - Disclosure - Property and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 100140 - Disclosure - Accrued Expenses and Other Current Liabilities link:presentationLink link:calculationLink link:definitionLink 100150 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 100160 - Disclosure - Liability Related to the Sale of Future Royalties link:presentationLink link:calculationLink link:definitionLink 100170 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 100180 - Disclosure - Series 1 Nonconvertible Preferred Stock link:presentationLink link:calculationLink link:definitionLink 100190 - Disclosure - Stock-Based Awards link:presentationLink link:calculationLink link:definitionLink 100200 - Disclosure - Net Income (Loss) Per Share link:presentationLink link:calculationLink link:definitionLink 100210 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 100220 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 100230 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 100240 - Disclosure - 401(k) Plan link:presentationLink link:calculationLink link:definitionLink 100250 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 100260 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 100270 - Disclosure - Fair Value of Financial Assets and Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 100280 - Disclosure - Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 100290 - Disclosure - Property and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 100300 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 100310 - Disclosure - Collaboration Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 100320 - Disclosure - Liability Related to the Sale of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 100330 - Disclosure - Stock-Based Awards (Tables) link:presentationLink link:calculationLink link:definitionLink 100340 - Disclosure - Net Income (Loss) Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 100350 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 100360 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 100370 - Disclosure - Selected Quarterly Financial Data (unaudited) (Tables) link:presentationLink link:calculationLink link:definitionLink 100380 - Disclosure - Nature of the Business - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100390 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100400 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment Estimated Useful Lives (Detail) link:presentationLink link:calculationLink link:definitionLink 100410 - Disclosure - Summary of Significant Accounting Policies - Diluted Net Loss Per Share Attributable to Common Stockholders With Anti-dilutive effect (Detail) link:presentationLink link:calculationLink link:definitionLink 100420 - Disclosure - Fair Value of Financial Assets and Liabilities - Financial Assets and Liabilities that were Subject to Fair Value Measurement on Recurring Basis (Detail) link:presentationLink link:calculationLink link:definitionLink 100430 - Disclosure - Fair Value of Financial Assets and Liabilities - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100440 - Disclosure - Fair Value of Financial Assets and Liabilities - Fair Value Measurements of the Company's Series 1 Nonconvertible Preferred Stock (Detail) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Fair Value of Financial Assets and Liabilities - Rollforward of Aggregate Fair Value of Company's Outstanding Series 1 Nonconvertible Preferred Stock (Detail) link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Marketable Securities - Fair Value of Available-for-Sale Marketable Securities by Type of Security (Detail) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Marketable Securities - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Property and Equipment, Net - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100500 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100510 - Disclosure - Collaboration Agreements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100520 - Disclosure - Collaboration Agreements - Summary of Royalty Tiers Associated with Cumulative Calendar Year Net Sales Allocated to Each Royalty-bearing Product (Detail) link:presentationLink link:calculationLink link:definitionLink 100530 - Disclosure - Liability Related to the Sale of Future Royalties - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100540 - Disclosure - Liability Related to the Sale of Future Royalties - Summary of the Liability Related to the Sale of Future Royalties (Detail) link:presentationLink link:calculationLink link:definitionLink 100550 - Disclosure - Stockholders' Equity - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100560 - Disclosure - Series 1 Nonconvertible Preferred Stock - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Stock-Based Awards - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Stock-Based Awards - Data Used to Determine Value of Stock Option Grants, Presented on Weighted Average Basis (Detail) link:presentationLink link:calculationLink link:definitionLink 100590 - Disclosure - Stock-Based Awards - Summary of Stock Option Activity Including Performance Based Options (Detail) link:presentationLink link:calculationLink link:definitionLink 100600 - Disclosure - Stock-Based Awards - Summary of PSUs and rTSRUs Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 100610 - Disclosure - Stock-Based Awards - Summary of Restricted Stock Unit Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 100620 - Disclosure - Stock-Based Awards - Stock-Based Compensation Expense (Detail) link:presentationLink link:calculationLink link:definitionLink 100630 - Disclosure - Leases - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100640 - Disclosure - Leases - Components of Lease Expense for Real Estate and Equipment Leases and Other Information Related to Leases (Detail) link:presentationLink link:calculationLink link:definitionLink 100650 - Disclosure - Leases - Schedule of Future Annual Minimum Lease Payments (Detail) link:presentationLink link:calculationLink link:definitionLink 100660 - Disclosure - Leases - Schedule of Lease Included in Balance Sheet (Detail) link:presentationLink link:calculationLink link:definitionLink 100670 - Disclosure - Income Taxes - Summary of Income Tax Benefit (Expense) (Detail) link:presentationLink link:calculationLink link:definitionLink 100680 - Disclosure - Income Taxes - Reconciliation of Income Tax Provision at Federal Statutory Income Tax Rate and Effective Tax Rate (Detail) link:presentationLink link:calculationLink link:definitionLink 100690 - Disclosure - Income Taxes - Changes in the Valuation Allowance for Deferred Tax Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 100700 - Disclosure - Income Taxes - Net Deferred Tax Assets and Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100710 - Disclosure - Income Taxes - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100720 - Disclosure - Income Taxes - Schedule of Reconciliation of Uncertain Tax Positions (Detail) link:presentationLink link:calculationLink link:definitionLink 100730 - Disclosure - 401(k) Plan - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink